P2X7-mediated ATP secretion is accompanied by depletion of cytosolic ATP
نویسندگان
چکیده
منابع مشابه
Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptor.
Matrix metalloproteinase-9 (MMP-9) activity is required for inflammatory response, leukocyte recruitment, and tumor invasion. There is increasing evidence suggesting that the P2X(7) receptor of mononuclear cells, which is activated by extracellular adenosine triphosphate (ATP), is involved in inflammatory responses. In this study, ATP caused a rapid release of MMP-9 and a moderate decrease in t...
متن کاملEffects of ATP and ATP inhibitors on the P2X7 receptor
................................................................................................iv Acknowledgements..................................................................................v Introduction...........................................................................................1 Literature Review...............................................................................
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It is known that glycine protects mammalian cells against ischaemic cell injury by preventing cellular membrane leakage. However, the molecular mechanisms have not yet been clearly elucidated. The purpose of the present study was to clarify whether GlyR (glycine receptor) acts as a key mediator in cytoprotection of glycine. cDNA encoding human GlyRa1 (a1-subunit of glycine receptor) was transfe...
متن کاملU937 cell necrosis mediated by peroxynitrite is not caused by depletion of ATP and is prevented by arachidonate via an ATP-dependent mechanism.
Exposure of U937 cells to an otherwise nontoxic concentration of peroxynitrite promotes a rapid necrotic response in the presence of pharmacological inhibitors of phospholipase A2. A 12-fold higher concentration of the oxidant, in the absence of additional treatments, caused remarkably greater DNA single-strand breakage, delayed formation of H2O2, and depletion of reduced glutathione but an ide...
متن کاملACCELERATED COMMUNICATION U937 Cell Necrosis Mediated by Peroxynitrite Is Not Caused by Depletion of ATP and Is Prevented by Arachidonate via an ATP-Dependent Mechanism
Exposure of U937 cells to an otherwise nontoxic concentration of peroxynitrite promotes a rapid necrotic response in the presence of pharmacological inhibitors of phospholipase A2. A 12fold higher concentration of the oxidant, in the absence of additional treatments, caused remarkably greater DNA singlestrand breakage, delayed formation of H2O2, and depletion of reduced glutathione but an ident...
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ژورنال
عنوان ژورنال: Purinergic Signalling
سال: 2019
ISSN: 1573-9538,1573-9546
DOI: 10.1007/s11302-019-09654-5